The No. 13 Notre Dame Fighting Irish (4-2) are set to host the No. 20 USC Trojans (5-1) in a rivalry game on Saturday. Kickoff at Notre Dame Stadium in South Bend, Indiana is scheduled for 7:30 p.m. ET. USC is looking to build off its dominant 31-13 win over Michigan on Oct. 11, while Notre Dame is aiming to win its fifth straight game after beating N.C. State 36-7 in its last outing. Notre Dame leads the all-time series 52-37-5

Notre Dame is a 10.5-point favorite in the latest USC vs. Notre Dame odds, while the over/under for total points scored is 59.5. Notre Dame is a -383 (risk $383 to win $100) favorite on the money line, with USC listed as a +301 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Notre Dame vs. USC picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, posting a 252-179-7 record since Week 1 of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman at 40-1 odds, bringing his net profit up to a whopping 96.95 units ($9,695.50 for a $100 bettor) since joining SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks could be way up.

Now, Kaylor has locked in a confident against-the-spread pick for USC vs. Notre Dame in their Week 8 matchup. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins USC vs. Notre Dame in their Week 8 matchup at Notre Dame Stadium in South Bend and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 252-179-7, returning $9,695 for $100 bettors, betting on college football since 2023, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates