USC vs. LSU prediction, odds, spread, line, start time: Proven expert releases college football picks, best bets, game props for Modelo Vegas Kickoff Classic

The No. 23 USC Trojans are set to take on the No. 13 LSU Tigers in the 2024 Modelo Vegas Kickoff Classic at Allegiant Stadium in Las Vegas on Sunday, Sept, 1. USC is looking to improve upon its 8-5 record in 2023, but will have to do so without 2022 Heisman Trophy winner Caleb Williams. Miller Moss is set to take over for Williams in Lincoln Riley's explosive offensive attack. Likewise, LSU has to deal with the loss of a Heisman Trophy winner (Jayden Daniels), and is coming off a solid 10-3 season in 2023. Garrett Nussmeier is set to take over as the Tigers' starting quarterback. 

Kickoff from Allegiant Stadium is scheduled for 7:30 p.m. ET. The Tigers are 4.5-point favorites in the latest LSU vs. USC odds via SportsLine consensus, while the over/under for total points scored is 66.5. LSU is a -185 (risk $185 to win $100) favorite on the money line, with USC listed as a +153 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any USC vs. LSU picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season WAY UP!

Now, Kaylor has locked in a confident against-the-spread pick for USC vs. LSU in their Modelo Vegas Kickoff Classic matchup at Allegiant Stadium in Las Vegas. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins LSU vs. USC in their Week 1 matchup in Las Vegas on Sunday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who went 107-45-2, returning $5,790 for $100 bettors, betting on college football in 2023, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates