USC vs. BYU odds, line, spread: Proven model reveals college football picks, predictions for Week 13, 2021

The USC Trojans will take on the BYU Cougars at 10:30 p.m. ET on Saturday, Nov. 27 at United Airlines Field at the Los Angeles Memorial Coliseum. The Trojans are 4-6 overall and 2-4 at home, while BYU is 9-2 overall and 3-1 on the road. 

The Cougars are favored by seven points in the latest USC vs. BYU odds from Caesars Sportsbook, and the over-under is set at 63.5. Before you make any BYU vs. USC picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated USC vs. BYU 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins USC vs. BYU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!