Ranked lightweights headline the marquee Saturday when third-ranked Dustin Poirier faces fifth-ranked Dan Hooker in the main event of UFC Fight Night: Poirier vs. Hooker in Las Vegas. Poirier is a -220 favorite (risk $220 to win $100) while Hooker is priced at +180 (risk $100 to win $180) in the latest Poirier vs. Hooker odds from William Hill US. 

Before making any UFC Fight Night: Poirier vs. Hooker picks, you NEED to see the UFC predictions from SportsLine MMA expert Brandon Wise.

Wise has been covering the sport for more than five years. He specializes in picking main-card fights for UFC, which has enabled him to be profitable every year! In fact, Wise went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249. He also nailed Khabib Nurmagomedov's destruction of Conor McGregor in 2018, Stipe Miocic's upset of Daniel Cormier, Max Holloway's downfall in 2019 and Justin Gaethje's TKO victory over Tony Ferguson in May. 

Across UFC 247, UFC 248, UFC 249 and UFC 250, Wise went a whopping 14-6 with his main-card picks, returning healthy profits for anyone following them. Last week, he called a dominant victory for Curtis Blaydes (-400) against Alexander Volkov (+320) in the main event. He also had Josh Emmett's (+115) upset of Shane Burgos (-135) in the co-main event. Anyone who has followed him is WAY UP! 

For UFC Fight Night: Poirier vs. Hooker, we can tell you Wise is backing Maurice Greene (-220) to come out on top against Gian Villante (+180) in a heavyweight battle. He's also backing one fighter whose striking game is "top-notch." You ABSOLUTELY need to see Wise's selections before making your picks.

Who wins Poirier vs. Hooker and every main-card bout at Saturday's UFC Fight Night? And how exactly does each fight end? ... Join SportsLine right now to see which fighters you need to be all over at UFC Fight Night: Poirier vs. Hooker on Saturday, all from the accomplished MMA analyst who has been profitable for five straight years!