UFC Fight Night odds, picks: Seasoned MMA analyst reveals selections for Adesanya vs. Pyfer and other matchups at Seattle on March 28

A pari of ranked UFC middleweights battle when fourth-ranked Israel Adesanya faces 14th-ranked Joe Pyfer in the main event at UFC Fight Night: Adesanya vs. Pyfer on Saturday at Climate Pledge Arena in Seattle. The preliminaries are set to begin at around 5 p.m. ET, with the main card at approximately 8 p.m. ET on Paramount+. Adesanya is coming off a loss by TKO to Nassourdine Imavov on Feb. 1, 2025. Pyfer, meanwhile, earned a submission win at 1:46 of the second round over Abusupiyan Magomedov at UFC 320 on Oct. 4, 2025.

Adesanya is a -130 favorite (risk $130 to win $100), while Pyfer comes back at +110 in the latest UFC Fight Night odds at DraftKings Sportsbook. The co-main event features a women's flyweight bout between third-ranked Alexa Grasso (+145) and fifth-ranked Maycee Barber (-175).      

Before locking in any UFC Fight Night picks, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley.

Over the past three-plus years, $100 bettors who have followed Marley's picks are up nearly $10,000, and since May 2018, he has returned more than $21,000! Anyone who has followed Marley could be way up. He went 9-4 in last weekend's card.

One of of Marley's UFC Fight Night picks: He is backing Chase Hooper to beat Lance Gibson Jr. via submission in a lightweight bout on the preliminary card.

"Gibson is the more well-rounded striker and wrestler, and he will be the stronger guy/better athlete," Marley said. "He isn't great anywhere, but he needs to keep this fight standing. Hooper is a dangerous submission grappler, and he knows he isn't a good striker. He should sell out for takedowns, and I'll take him to get a submission."

Marley also has strong picks for Adesanya vs. Pyfer and other bouts on the UFC Fight Night: Adesanya vs. Pyfer card. He's also backing a fighter who "will be much more active and dangerous," to emerge with a big victory. You MUST see his UFC Fight Night: Adesanya vs. Pyfer picks before making any of your own.

Who wins Adesanya vs. Pyfer, and which other fighters do you need to back with UFC Fight Night predictions? ... Join SportsLine now to see which fighters you need to be all over Saturday, all from the expert who's up nearly $10,000 on MMA picks over the last three-plus years!