Alex Pereira will defend his light heavyweight belt against top-rated challenger Jiri Prochazka in the main event of UFC 303 on Saturday. The main card is set for 10 p.m. ET from T-Mobile Arena in Las Vegas. Pereira is a -160 favorite (risk $160 to win $100), while Prochazka comes back at +135 in the latest UFC 303: Pereira vs. Prochazka 2 odds. Diego Lopes is the -150 favorite against Brian Ortega (+125) in the co-main event.

Before locking in your picks for UFC 303: Pereira vs. Prochazka 2, make sure you see the MMA predictions and betting advice from SportsLine expert Daniel Vithlani.

Vithlani is a highly analytical UFC bettor who has been a consistent winner for SportsLine members since making his debut in January 2023 with a 5-0 record for UFC 283. In the last 12 UFC pay-per-view events, Vithlani has gone 8-4 on main-event picks and his main-card selections in that span have netted his followers a profit of more than $1,500. 

His highlights include calling an upset for Sean O'Malley (+210) against Aljamain Sterling (-250) at UFC 292 as part of a 4-1 main card and his UFC 299 winners included underdog selections on Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130). Anyone who has followed him is WAY UP!

This week at UFC 303: Pereira vs. Prochazka 2, we can tell you Vithlani is going with Anthony Smith (+120) to get his hand raised against Roman Dolidze (-140) in a light heavyweight matchup on the main card.

Vithlani has strong picks for Pereira vs. Prochazka 2 and other bouts on the UFC Fight Night card. He's also putting two units down on another underdog he expects to win outright, saying his "movement and speed are dazzling!" You ABSOLUTELY need to see his UFC 303 picks before making any of your own!

Who wins UFC 303: Pereira vs. Prochazka 2, and which fighter is a MUST-BACK? Join SportsLine now to see which fighters you need to be all over, all from the expert who profited more than $1,500 in UFC main-card picks!