Heavyweight champion Francis Ngannou will face interim champion Ciryl Gane for the unified belt in the main event of UFC 270 on Saturday. The main UFC 270 fight card is set for 10 p.m. ET from the Honda Center in Anaheim. Ngannou won the title last March with a second-round knockout of former champion Stipe Miocic. His first title defense comes against the undefeated and celebrated Gane, who won the interim belt with a third-round stoppage of veteran contender Derrick Lewis last August.

Gane is a -160 favorite (risk $160 to win $100), while Ngannou is priced at +140 (risk $100 to win $140) in the latest Caesars Sportsbook MMA odds for UFC 270. Before making any UFC 270: Ngannou vs. Gane picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past 35 months, $100 bettors who have followed Marley's picks are up more than $13,000! 

The accomplished MMA analyst has provided consistent winners for SportsLine members for nearly three years. He has now nailed 44 of his last 73 UFC main-event picks, a stretch that included a streak of five consecutive underdogs in 2020!  Just last week at UFC Fight Night, Marley told SportsLine members to back Calvin Kattar (+200) against Giga Chikadze (-240) in the featherweight showdown in the main event. Anyone who has consistently followed Marley is WAY UP!

This week at UFC 270, we can tell you Marley is backing Trevin Giles (+110) to get the best of Michael Morales (-130) in a matchup of welterweight prospects.

Marley also has strong picks for Ngannou vs. Gane every other bout on the UFC 270 card. He's also backing a fighter who has "looked amazing and pretty unbeatable" to emerge with a dominant victory! You ABSOLUTELY need to see Marley's other UFC 270 picks before making any of your own.

Who wins Ngannou vs. Gane? And which fighter is a MUST-BACK? ... Join SportsLine right now to see which fighters you need to be all over Saturday, all from the expert who's up more than $13,000 on MMA picks!