Welterweight champ Kamaru Usman defends his title Saturday in a rematch against fourth-rated contender Jorge Masvidal in the main event of UFC 261 in Jacksonville. The main UFC 261 fight card is set for 10 p.m. ET. Usman is a -400 favorite (risk $400 to win $100), while Masvidal is a +320 underdog (risk $100 to win $320) in the latest Masvidal vs. Usman odds from William Hill Sportsbook.

Before making any UFC 261 picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past 26 months, $100 bettors who have followed Marley's picks are up more than $19,000. The accomplished MMA analyst has seen memorable run in 2020 carry over into 2021. He has now nailed 29 of his last 44 UFC main-event picks, a stretch that included a streak of five consecutive underdogs!

At UFC Fight Night last week, Marley's winners included telling SportsLine members to expect a unanimous-decision victory for Robert Whittaker (-260) against Kelvin Gastelum (+220) in the middleweight main event. Anyone who has followed Marley is WAY UP! 

This week at UFC 261, we can tell you Marley is picking Brendan Allen (-130) to get past Karl Roberson (+110) in a battle of middleweight prospects. He's also backing a fighter who "can win with a TKO, submission, or decision!" You ABSOLUTELY need to see Marley's other UFC 261 picks before making any of your own.

Who wins Usman vs. Masvidal 2 and every bout on the UFC 261 card? And which fighter is a MUST-BACK? ... Join SportsLine right now to see which fighters you need to be all over Saturday, all from the expert who's up more than $19,000 on MMA picks!