Israel Adesanya defends his middleweight belt against second-ranked contender Paulo Costa in the main event of UFC 253 on Saturday in a rare matchup of undefeated fighters. Adesanya is a -170 favorite (risk $170 to win $100), while Costa is offered at +150 (risk $100 to win $150) in the latest William Hill odds for Adesanya vs. Costa. 

Before making any picks for UFC 253, you NEED to see the UFC predictions from SportsLine MMA expert Brandon Wise. He specializes in picking main-card fights for UFC, which has enabled him to be profitable every year! In fact, Wise went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249. He also nailed Khabib Nurmagomedov's destruction of Conor McGregor in 2018, Stipe Miocic's upset of Daniel Cormier, Max Holloway's downfall in 2019 and Justin Gaethje's TKO victory over Tony Ferguson in May. 

Since the UFC returned following a period of inactivity due to the coronavirus pandemic, Wise has gone 49-29-1 while nailing the method of victory 34 times!  Last week at UFC Fight Night, he called a dominant victory for Colby Covington (-340) over Tyron Woodley (+280) in the welterweight main event. He also nailed the winner and method of victory in three of the other four main-card fights. 

For UFC 253, we can tell you Wise is backing Ketlen Vieira (-170) to get past Sijara Eubanks (+150) in a matchup of women's bantamweight contenders. You ABSOLUTELY need to see Wise's selections before making your picks!

Who wins Adesanya vs. Costa and every bout on Saturday's UFC 253 main card? And how exactly does each fight end? ... Join SportsLine here to see which fighters you need to be all over at UFC 253 on Saturday, all from the accomplished MMA analyst who has been profitable for five straight years!