UConn vs. South Carolina odds, prediction: 2026 NCAA Women's Tournament Final Four picks from proven experts on 209-128 run

Top seeds clash in the 2026 NCAA Tournament women's Final Four as the UConn Huskies take on the South Carolina Gamecocks on Friday in a rematch of last year's championship game. UConn won 82-59 in 2025. This year, the Huskies (38-0) rolled through the Fort Worth I bracket, while South Carolina (35-3) was largely untested in the Sacramento 4 bracket. 

The game from Mortgage Matchup Center in Phoenix tips off at 7 p.m. ET. UConn is a 6.5-point favorite, while the over/under is 136.5 in the latest UConn vs. South Carolina odds. 

Before making any South Carolina vs. UConn picks, check out what SportsLine college basketball experts Calvin Wetzel and Aaron Barzilai have to say.

Barzilai is a Ph.D. from Stanford who served as Director of Basketball Analytics for the Philadelphia 76ers. Eight years ago, he founded HerHoopStats.com -- a groundbreaking website that unlocks insights about the women's game. Wetzel, the site's lead betting writer, incorporates his mathematical background and strong knowledge of women's hoops to turn the site's prediction model into picks. 

Wetzel and Barzilai are 209-128-1 (+54.51 units) for ROI of 19.63% over the past two season on their women's college basketball picks. On the SportsLine discord this season, Wetzel is 12-8, +2.94 units, +13.06% ROI.

Now Wetzel and Barzilai have broken down UConn vs. South Carolina from every angle and locked in their picks. They are leaning Over on the total, and they've also found a critical X-factor that has them jumping on one side the spread! 

So who covers in South Carolina vs. UConn, and what critical X-factor do you need to know about? Join SportsLine right now to see which side of the spread you need to jump on, all from the experts on a sizzling 209-128 run on CBB picks!