Twins vs. Guardians odds, picks: Advanced computer MLB model releases selections for Tuesday matchup

The Cleveland Guardians and Minnesota Twins face off to begin a doubleheader at 1:10 p.m. ET on Tuesday. Cleveland is listed as a -115 favorite (risk $115 to win $100) at Caesars Sportsbook, while the Over-Under is set at 8.5 (see up-to-date odds for every game this week on our MLB odds page). 

Before making any Twins vs. Guardians picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

The model knows the Twins opened the series with 11 runs on 14 hits on Monday. Minnesota is a powerful offensive team, scoring 339 runs this season. The Twins are in the top three of the AL in hits, doubles and batting average in 2022. Minnesota also has a top-five slugging percentage (.414) and overall success through nearly half of the season.

The model also knows the Guardians have an edge at home in front of a favorable crowd. Cleveland has 16 triples this season, No. 2 in the AL, and the Guardians are also in the top five of the league in doubles. Cleveland also has the fewest strikeouts (480) in the AL by a wide margin, with team speed to rack up 47 stolen bases. The Guardians boast a .249 batting average and plenty of firepower.

Now, it has set its sights on Twins vs. Guardians. We can tell you the model is leaning under the total, and it also says one team has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks.

Who wins Twins vs. Guardians? And which team has ALL the value on the money line? ... Join SportsLine right now to find out which side of the Twins vs. Guardians matchup you should be all over Tuesday, all from the model on a roll on MLB picks!