Toledo vs. Notre Dame odds, line, spread: Proven model reveals college football picks, predictions for Week 2, 2021

Notre Dame pulled off a 41-38 win against Florida State last week and will return home for Week 2 of the 2021 season. The Fighting Irish will host 1-0 Toledo at Notre Dame Stadium on Saturday at 2:30 p.m. ET. 

The Rockets dusted off Norfolk State in a 49-10 blowout victory last weekend but will face a much more challenging opponent in their second game of the season. Notre Dame is favored by 16.5 points in the latest Toledo vs. Notre Dame odds from Caesars Sportsbook, and the over-under is set at 55.5.

Before you make any Toledo vs. Notre Dame picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Toledo vs. Notre Dame 10,000 times, and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Toledo vs. Notre Dame? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.