Toledo vs. Louisville odds, line: 2025 college football picks for Boca Raton Bowl matchup from proven model

The Toledo Rockets will take on the Louisville Cardinals in the 2025 Boca Raton Bowl on Tuesday afternoon. The Rockets (8-4), who tied for second in the Mid-American Conference at 6-2, have won four in a row. The Cardinals (8-4), who tied for seventh in the Atlantic Coast Conference, have lost three of four. Toledo quarterback Tucker Gleason is expected to miss this game due to injury.

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Kickoff from Flagler Credit Union Stadium in Boca Raton, Fla., is at 2 p.m. ET.  The Cardinals are 11.5-point favorites in the latest Toledo vs. Louisville odds, while the over/under for total points scored is 43.5 via SportsLine consensus. 

Before making any Toledo vs. Louisville picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is 31-19 on its top-rated college football money-line picks since the beginning of the 2024 season. 

The model has simulated Toledo vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 50% of simulations!

So who wins Toledo vs. Louisville, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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