Toledo vs. Louisville odds, line: 2025 college football picks for Boca Raton Bowl matchup from proven model

The Toledo Rockets will take on the Louisville Cardinals in the Boca Raton Bowl on Tuesday afternoon. Toledo closed out the regular season with a 21-3 win at Central Michigan on Nov. 29, while Louisville downed Kentucky 41-0 that same day. The Rockets (8-4), who tied for second in the Mid-American Conference at 6-2, have won four in a row. The Cardinals (8-4), who tied for seventh in the Atlantic Coast Conference, have lost three of four.

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Both teams will be without multiple players due to injury or the transfer portal. Toledo quarterback Tucker Gleason (undisclosed) is doubtful after getting injured against Central Michigan. Among the Rockets in the portal include defensive end Malachi Davis, safety Braden Awls and linebacker Chris D'Appolonia. Louisville wide receiver Chris Bell (knee) is out. Among those opting out for the Cardinals include defensive tackle Rene Konga and defensive end Wesley Bailey.

Kickoff from Flagler Credit Union Stadium in Boca Raton, Fla., is at 2 p.m. ET. Louisville leads the all-time series 5-3. The Cardinals are 6.5-point favorites in the latest Toledo vs. Louisville odds, while the over/under for total points scored is 44.5 via SportsLine consensus. 

Before making any Toledo vs. Louisville picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Toledo vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Toledo vs. Louisville, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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