The Los Angeles Lakers will look to stay alive when they take on the Minnesota Timberwolves in Game 5 of their best-of-seven Western Conference first-round series on Wednesday. The Timberwolves (49-33), the sixth seed in the conference, are 25-18 on the road this season, including the postseason. The Lakers (50-32), the third seed in the West, are 32-11 on their home court in 2024-2025. Minnesota won Game 4 on Sunday, 116-113, as Anthony Edwards scored 43 points, one shy of matching his postseason career-high. The teams split four regular-season meetings, with the home team winning each game.

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Tipoff from Crypto.com Arena in Los Angeles is set for 10 p.m. ET. Los Angeles won the two previous playoff series with Minnesota. The Lakers are 5.5-point favorites in the latest Timberwolves vs. Lakers odds, while the over/under for total points scored is 210. The Lakers are -240 on the money line (risk $240 to win $100), while the Timberwolves are +197 (risk $100 to win $197).

Before making any Timberwolves vs. Lakers picks, check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the second full week of the 2025 NBA playoffs on a sizzling 156-116 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It is also 22-11 (67%) on top-rated NBA against-the-spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Timberwolves vs. Lakers 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits in over 60% of simulations in an A-rated pick!

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