Tigers vs. Guardians odds, line, start time, picks, best bets for AL Wild Card Game 2 matchup from proven model

The Detroit Tigers (87-75) will visit the Cleveland Guardians (88-74) in Game 2 of the American League Wild Card on Wednesday afternoon, with Detroit holding a 1-0 series lead. The Tigers won Game 1, 2-1, behind a 14-strikeout performance from Tarik Skubal after the Guardians won the regular season series between the two, 8-5. Tanner Bibee (12-11, 4.24 ERA) will take the ball for Cleveland, while Detroit will counter with Casey Mize (14-6, 3.87).

First pitch is at 1:08 p.m. ET from Progressive Field in Cleveland. The Tigers are seeking their second ALDS appearance in as many years. Cleveland is a -133 favorite on the money line (risk $129 to win $100) in the latest Tigers vs. Guardians odds, with Detroit at +112 (risk $100 to win $112). The total number of runs Vegas thinks will be scored, or the over/under, is 7 in the latest MLB odds. 

Before you make any Tigers vs. Guardians picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the 2025 MLB playoffs a profitable 34-28 on top-rated MLB money-line picks this season. It has excelled making home run prop picks this season, returning more than 35 units of profit. Anybody following could have seen strong returns!

The model has simulated Guardians vs. Tigers 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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