Thunder vs. Spurs prediction, odds, line: Proven model reveals 2026 NBA picks for Feb. 4

The top two teams in the Western Conference will meet on Wednesday's NBA schedule as the Oklahoma City Thunder visit the San Antonio Spurs. The Thunder (40-11) are 18-6 on the road and are coming off a 128-92 win over Orlando. The Spurs (33-16) are 17-6 at home and also defeated the Magic in their last contest by a 112-103 score. San Antonio has won three of four matchups this season, but OKC claimed the last one in January. OKC released a lengthy injury list on Wednesday afternoon that has ruled out Shai Gilgeous-Alexander (abdominal) and Chet Holmgren (back) among others, leading to significant line movement.

Tipoff is at 9:30 p.m. ET from Frost Bank Center in San Antonio. The latest Spurs vs. Thunder odds list the Spurs as the 9.5-point favorites, with the over/under at 218.5. OKC opened at -2 before all the injury updates. 

Before making any Thunder vs. Spurs picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 16 of the 2025-26 NBA season on a sizzling 38-16 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Thunder vs. Spurs 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits well over 50% of the time!

Who wins Spurs vs. Thunder, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the Thunder vs. Spurs spread you should be all over, all from the model on a 38-16 roll on top-rated NBA spread picks!