Rams vs. Seahawks line, odds: Proven model releases spread pick for 2025 NFL Week 16 matchup on Thursday Night Football

The NFC West lead will be on the line when the Los Angeles Rams battle the Seattle Seahawks in a matchup of two of the best teams in the NFL on 'Thursday Night Football.' Los Angeles is coming off a 41-34 win over the Detroit Lions, while Seattle squeaked past the Indianapolis Colts on Sunday. The Rams (11-3), who have won two in a row, are 5-2 on the road this season. The Seahawks (11-3), who have won four consecutive games, are 5-2 on their home field. Rams wide receiver Davante Adams (hamstring) is doubtful after missing practice on Monday, Tuesday and Wednesday. Seattle OL Charles Cross (hamstring) has been ruled out.

Kickoff from Lumen Field in Seattle is set for 8:15 p.m. ET. The all-time series is tied 28-28, with Los Angeles earning a 21-19 win in their last meeting in November. The Seahawks are 1.5-point favorites in the latest Rams vs. Seahawks odds, while the over/under for total points scored is 42.5. The O/U has dropped 4 points since opening at 46.5, as there's nearly a 90% chance of rain and 15 m.p.h. winds expected at kickoff. Seattle is at -122 on the money line (risk $122 to win $100), with L.A. at +103 (risk $100 to win $103)

Before making any Rams vs. Seahawks picks, or 2025 NFL Week 16 predictions of your own, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Rams vs. Seahawks.

We can tell you it's leaning Over the point total, but also says that one side of the spread has all of the value! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

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