Thunder vs. Bucks odds, line: Proven model reveals picks for NBA matchup on Wednesday, January 21

The Oklahoma City Thunder face the Milwaukee Bucks in a key interconference NBA matchup on Wednesday night. Oklahoma City is coming off a 136-104 win at Cleveland on Monday, while Milwaukee posted a 112-110 win at Atlanta that same day. The Thunder (36-8), who lead the Northwest Division, are 16-5 on the road this season. The Bucks (18-24), who are fourth in the Central Division, are 9-10 on their home court. Oklahoma City will be without Alex Caruso (groin), Jalen Williams (back) and Isaiah Hartenstein (calf).

Tip-off from Fiserv Forum in Milwaukee is set for 9:30 p.m. ET. The Bucks lead the all-time series 77-76, but the Thunder have won the last three meetings. Oklahoma City is a 9.5-point favorite in the latest Thunder vs. Bucks odds from DraftKings Sportsbook, while the over/under for total points scored is 226.5. 

Before making any Thunder vs. Bucks picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 14 of the 2025-26 NBA season on a sizzling 35-15 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Thunder vs. Bucks 10,000 times and the results are in. We can tell you that the model is going Over on the point total, and it also says one side of the spread hits in well over 50% of simulations!

Who wins Thunder vs. Bucks, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 35-15 roll on top-rated NBA picks!