Texas Tech vs. Iowa State odds, prediction: 2026 men's college basketball picks for Feb. 28 from proven model

Big 12 powers meet on Saturday when the No. 4 Iowa State Cyclones host the No. 16 Texas Tech Red Raiders on CBS and Paramount+ (sign up here). Iowa State is 24-4 on the season, while Texas Tech is 21-7. Both teams are 11-4 in the Big 12, tied with Kansas and Houston for second place, trailing only Arizona. 

Tipoff from Hilton Coliseum is set for 4 p.m. ET. The Cyclones are 9.5-point favorites in the latest Iowa State vs. Texas Tech odds, with the over/under at 146.5. 

Before making any Texas Tech vs. Iowa State picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated this matchup 10,000 times and the results are in. The model is going Over, and it also says one side of the spread hits 60% of the time!

So who wins Texas Tech vs. Iowa State, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!