TCU vs. Duke odds, prediction: 2026 NCAA Tournament picks from proven model

The ninth-seeded Texas Christian Horned Frogs meet the top-seeded Duke Blue Devils in the second round of the NCAA Tournament East Region on Saturday. TCU advanced with a 66-64 win over eighth-seeded Ohio State on Thursday, while Duke survived with a 71-65 victory over 16th-seeded Siena. The Horned Frogs (23-11), who finished sixth in the Big 12 at 11-7, have won seven of their past eight games. The Blue Devils (33-2), who won the ACC regular season (17-1) and tournament titles, have won 12 games in a row. 

Tipoff from Bon Secours Wellness Arena in Greenville, S.C., is set for 5:15 p.m. ET. Duke is an 11.5-point favorite in the latest TCU vs. Duke odds, while the over/under for total points scored is 140.5. 

Before making any TCU vs. Duke picks, you NEED to see the basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated TCU vs. Duke 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits well over 60% of the time!

So who wins TCU vs. Duke, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!