Texas A&M vs. Houston odds, prediction: 2026 NCAA Tournament picks from proven model

The 10th-seeded Texas A&M Aggies battle the second-seeded Houston Cougars in the second round of the NCAA Tournament South Region on Saturday. Texas A&M advanced after defeating seventh-seeded Saint Mary's 63-50 on Thursday, while Houston cruised past 15th-seeded Idaho 78-47. The Aggies (22-11), who tied for fourth in the Southeastern Conference at 11-7, have won three of their last four games. The Cougars (29-6), who finished second in the Big 12 Conference at 14-4, have won six of their last seven.

Tipoff from the Paycom Center in Oklahoma City is set for 6:10 p.m. ET. Houston leads the all-time series 53-34, including a 100-95 overtime win in the 2024 NCAA Tournament. Houston is a 10.5-point favorite in the latest Texas A&M vs. Houston odds, while the over/under for total points scored is 141.5. 

Before making any Texas A&M vs. Houston picks, you NEED to see the basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Texas A&M vs. Houston 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in over 50% of the simulations!

So who wins Texas A&M vs. Houston, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!