Tennessee vs. Vanderbilt odds, line: 2025 college football picks for Week 14 from proven model

Longtime in-state rivals meet on Saturday as the No. 12 Vanderbilt Commodores (9-2) take on the 18th-ranked Tennessee Volunteers (8-3). A win gives Vanderbilt a College Football Playoff case, while the Vols will be looking to play spoiler and upgrade their postseason destination in the first ever matchup of these teams when both sides are ranked. Tennessee running back Peyton Lewis is listed as questionable.

Kickoff at Neyland Stadium is at 3:30 p.m. ET. The Vols are 2.5-point favorites in the latest Tennessee vs. Vanderbilt odds, while the over/under is 66.5.

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Before making any Vanderbilt vs. Tennessee picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Tennessee vs. Vanderbilt 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hit nearly 60% of the time!

So who wins Vanderbilt vs. Tennessee, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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