Tennessee vs. South Carolina odds, prediction: 2026 SEC men's college basketball picks from proven model

Teams looking to get back on track battle when the 23rd-ranked Tennessee Volunteers face the South Carolina Gamecocks in a key Southeastern Conference matchup on Tuesday. Tennessee is coming off a 71-69 loss to the Alabama Crimson Tide on Saturday, while South Carolina dropped an 87-68 decision at Georgia that same day. The Volunteers (20-9, 10-6 SEC), who are tied for fourth in the conference, are 4-5 on the road this season. The Gamecocks (12-17, 3-13 SEC), who are tied for 15th in the league, are 11-7 on their home court. Tennessee's Nate Ament (leg) will not play.

Tip-off from Colonial Life Arena in Columbia, S.C., is set for 6 p.m. ET. Tennessee leads the all-time series 54-29, including a 20-17 edge in games played in Columbia. Tennessee is an 8.5-point favorite in the latest Tennessee vs. South Carolina odds from DraftKings Sportsbook, while the over/under for total points scored is 144.5. 

Before making any Tennessee vs. South Carolina picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered Week 18 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 23-17 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Tennessee vs. South Carolina 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits in 60% of simulations!

So who wins Tennessee vs. South Carolina, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!