Tennessee vs. Missouri odds, line: 2025 college basketball picks, February 5 best bets by proven model

The No. 15 Missouri Tigers will aim for their third consecutive win over a top-20 team when they face the No. 4 Tennessee Volunteers on Wednesday night in an SEC showdown. Missouri is coming off wins over then-No. 16 Ole Miss and then-No. 14 Mississippi State, crushing the Bulldogs in an 88-61 final on Saturday. Tennessee is coming off an impressive showing of its own, beating then-No. 5 Florida by 20 points on Saturday.  

Tipoff is set for 7 p.m. ET on Wednesday at Thompson-Boling Arena. Tennessee is favored by 10 points in the latest Tennessee vs. Missouri odds, while the over/under is 134.5 points, per SportsLine consensus. Before entering any Missouri vs. Tennessee picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 14 of the 2024-25 season on a 208-149 betting roll (+2275) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Tennessee vs. Missouri 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

So who wins Tennessee vs. Missouri? And which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.