Tennessee vs. Louisville odds, prediction: 2025 men's college basketball picks from proven model

The No. 11 Louisville Cardinals travel to take on the 20th-ranked Tennessee Volunteers on Tuesday. The Cardinals have raced to a 9-1 start. Tennessee, meanwhile, opened the season 7-0 with a win over Houston, but has since dropped three straight. 

Tipoff from Knoxville is set for 7 p.m. ET. Tennessee is a 1.5-point favorite, while the over/under is 157.5 in the latest Tennessee vs. Louisville odds. 

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Before making any Tennessee vs. Louisville picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and enters Week 7 on a sizzling 7-1 run on top-ranked over/under picks. Anyone following could have seen HUGE returns!

The model has simulated Tennessee vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Tennessee vs. Louisville, and which side hits in well over 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!

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