Tennessee vs. Houston odds, prediction: 2025 NCAA Tournament Elite Eight picks from proven model

The Midwest Region title and a spot in the Final Four is on the line when the second-seeded Tennessee Volunteers battle the top-seeded Houston Cougars Sunday on CBS. The Volunteers (30-7), who are in the Elite Eight for the second year in a row and third time all-time, have never advanced to the Final Four. The Cougars (33-4), who are in the Elite Eight for the eighth time, are looking to make it to the Final Four for the seventh time and first since 2021.

Tip-off from Lucas Oil Stadium in Indianapolis is set for 2:20 p.m. ET. Houston is a 2.5-point favorite in the latest Tennessee vs. Houston odds from SportsLine consensus, while the over/under for total points scored is 126.5, up three from the opening line. The over/under for total points scored in the first half is 58.5. 

Before making any Tennessee vs. Houston picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-168 roll (+1815) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and has nailed 25 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Tennessee vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Tennessee vs. Houston, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-168 (+1815) on top-rated college basketball pick and has nailed 25 first-round upsets by double-digit seeds!