Tennessee State vs. Iowa State odds, prediction: 2026 NCAA Tournament picks from proven model

The 15th-seeded Tennessee State Tigers clash with the second-seeded Iowa State Cyclones in the first round of the NCAA Tournament Midwest Region on Friday. Tennessee State is coming off a 93-67 win over Morehead State in the championship game of the Ohio Valley Conference Tournament on March 7. Iowa State dropped an 82-80 decision to eventual champion Arizona in the Big 12 Conference Tournament semifinals on March 13. The Tigers (23-9), who have won six in a row, tied with Morehead State at 15-5 for the OVC regular-season title. The Cyclones (27-7), who tied for third in the Big 12 standings at 12-6, have won three of their last four games.

Tip-off from Enterprise Center in St. Louis is set for 2:50 p.m. ET. Iowa State leads the all-time series 4-0, last playing in 2009. Iowa State is a 24.5-point favorite in the latest Tennessee State vs. Iowa State odds from DraftKings Sportsbook, while the over/under for total points scored is 149.5. 

Before making any Tennessee State vs. Iowa State picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Tennessee State vs. Iowa State 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread has all the value!

So who wins Tennessee State vs. Iowa State, and which side of the spread has all the value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!