Syracuse vs. San Diego State line, picks: Advanced computer college basketball model releases selections for NCAA Tournament matchup

A 2021 NCAA Tournament Midwest Region matchup is set to take place at Hinkle Fieldhouse in Indianapolis at 9:40 p.m. ET Friday on CBS, with the Syracuse Orange facing the San Diego State Aztecs. San Diego State is favored by three points at William Hill Sportsbook, while the Over-Under is set at 138.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Syracuse vs. San Diego State picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,600 for $100 players on its top-rated college basketball picks against the spread. It has also returned over $400 on all top-rated college basketball picks this season. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Syracuse vs. San Diego State. We can tell you the model is leaning Over the total, and it also has generated a pick that hits in over 50 percent over simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Syracuse vs. San Diego State? And which side of the spread hits in over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Syracuse vs. San Diego State spread you should be all over Friday, all from the model on a roll on college basketball picks!