Syracuse vs. North Carolina odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

The 16th-ranked North Carolina Tar Heels look to win their fourth game in a row when they battle the Syracuse Orange in a key Atlantic Coast Conference matchup on Monday. Syracuse is coming off an 86-72 win over Notre Dame on Saturday, while North Carolina defeated Georgia Tech 91-75 that same day. The Orange (13-9, 4-5 ACC), who are tied for 10th in the conference, are 2-2 on the road this season. The Tar Heels (17-4, 5-3 ACC), who are sixth in the conference, are 12-0 on their home floor this season.

Tip-off from the Dean E. Smith Center in Chapel Hill, N.C., is set for 7 p.m. ET. North Carolina leads the all-time series 18-7, and has won 14 of the last 17 meetings. North Carolina is a 10.5-point favorite in the latest Syracuse vs. North Carolina odds from DraftKings Sportsbook, while the over/under for total points scored is 155.5. 

Before making any Syracuse vs. North Carolina picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 13 on a sizzling 10-1 run on top-ranked over/under picks dating back to last year, and it is on a 6-0 roll on side picks. Anyone following could have seen HUGE returns!

The model has simulated Syracuse vs. North Carolina 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits nearly 60% of the time!

So who wins Syracuse vs. North Carolina, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!