Teams on the fringes of the NFL playoff picture will clash on Monday Night Football when the Pittsburgh Steelers meet the Indianapolis Colts. The Steelers (3-7), who are looking to avoid their first losing record in two decades, have had just six losing seasons since 1971. The Colts (4-6-1), who have made the postseason just twice in the past seven years, have not finished lower than third in the AFC South since 2011. Pittsburgh has won the last seven regular-season meetings between the teams.

Kickoff is set for 8:15 p.m. ET from Lucas Oil Stadium in Indianapolis. Indianapolis is favored by two points in the latest Steelers vs. Colts odds at Caesars Sportsbook, while the over/under is 39.5. Before making any Steelers vs. Colts picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model knows Indianapolis quarterback Matt Ryan completed 23 of 32 attempts (71.9%) for 213 yards last week against Philadelphia and will look for his third game in a row without an interception. Ryan has seven touchdowns with one interception and a 104.2 rating in four home starts this season. He has 350 or more passing yards in two of his past three home starts and is looking for his third start in a row versus Pittsburgh with 285 or more passing yards and a 95-plus rating.

The model also knows running back Najee Harris tops the Steelers with 148 carries for 550 yards (3.7 average) and three touchdowns. Harris also has 28 receptions for 138 yards (4.9 average) and two scores, converting nine first downs in the passing attack. Harris has rushed for 189 yards over the past two games, including 99 in a 20-10 over the New Orleans Saints on Nov. 13.

Now, the model has set its sights on Steelers vs. Colts on Monday Night Football. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in nearly 60% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Steelers vs. Colts on Monday Night Football? And which side of the spread hits in nearly 60% of simulations? ... Join SportsLine right now to find out which side of the Steelers vs. Colts spread you should be all over, all from the model on a 155-109 roll on NFL picks!