St. John's vs. Duke odds, prediction: 2026 NCAA Tournament picks from proven model

The fifth-seeded St. John's Red Storm clashes with the top-seeded Duke Blue Devils in an NCAA Tournament East Region Sweet 16 matchup on Friday. St. John's is coming off a 67-65 last-second victory over Kansas on Sunday in the second round, while Duke defeated TCU 81-58 on Saturday. The Red Storm (30-6), who won the Big East at 18-2 and claimed the conference tournament title, have won eight in a row. The Blue Devils (34-2), who won the Atlantic Coast Conference at 17-1 as well as the ACC Tournament crown, have won 13 straight. Duke is without Caleb Foster (foot).

Tip-off from Capital One Arena in Washington, D.C., is set for 7:10 p.m. ET. Duke leads the all-time series 17-7, including a 91-61 win in their last meeting in 2019. Duke is a 6.5-point favorite in the latest St. John's vs. Duke odds, while the over/under for total points scored is 142.5. Before making any St. John's vs. Duke picks, you NEED to see the basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 Sweet 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated St. John's vs. Duke 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in nearly 60% of the simulations!

So who wins St. John's vs. Duke, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!