Spurs vs. Rockets prediction, odds, line: Proven model reveals NBA picks for matchup on Wednesday, January 28

A Texas showdown takes place on Wednesday's NBA schedule as the San Antonio Spurs visit the Houston Rockets. The Spurs (31-15) have alternated wins and losses over their last four, most recently suffering a defeat to New Orleans on Sunday. The Rockets (28-16) have won five of their last six and are coming off a Monday victory over Memphis. San Antonio leads the all-time series 120-101.

Tipoff is at 9:30 p.m. ET from the Toyota Center in Houston. The latest Rockets vs. Spurs odds have Houston as 2.5-point favorites per DraftKings Sportsbook, while the over/under for total points scored is 220.5. 

Before making any Spurs vs. Rockets picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 15 of the 2025-26 NBA season on a sizzling 37-16 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Rockets vs. Spurs 10,000 times and the results are in. We can tell you that the model is going Over on the point total, and it also says one side of the spread hits in almost 70% of simulations!

Who wins Spurs vs. Rockets, and which side of the spread hits almost 70% of the time? ... Join SportsLine right now to find out which side of the Rockets vs. Spurs spread you should be all over, all from the model on a 37-16 roll on top-rated NBA picks!