Spurs vs. Lakers odds, line: Proven model reveals picks for NBA Cup quarterfinal matchup on December 10

The San Antonio Spurs battle the Los Angeles Lakers in a Western Conference NBA Cup quarterfinal on Wednesday, making it a great time to use the latest Underdog promo code CBSSPORTS2. San Antonio advanced by winning Group C with a 3-1 record, while Los Angeles won Group B with a 4-0 record. The Spurs (16-7), who are second in the Southwest Division, are 7-3 over the last 10 games. The Lakers (17-6), who lead the Pacific Division, are 7-3 on their home floor this season. San Antonio center Victor Wembanyama (calf) has been ruled out. 

Tipoff from Crypto.com Arena in Los Angeles is set for 10 p.m. ET. The Lakers lead the all-time series 99-94, and have won five of the last six meetings, including two in a row. Los Angeles is a 7.5-point favorite in the latest Spurs vs. Lakers odds from DraftKings Sportsbook, while the over/under for total points scored is 241.5.    

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Before making any Spurs vs. Lakers picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 8 of the 2025-26 NBA season on a sizzling 29-14 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Spurs vs. Lakers 10,000 times and the results are in. We can tell you that the model is going Under on the point total, and it also says one side of the spread hits nearly 60% of the time!

Who wins Spurs vs. Lakers, and which side of the spread hits nearly 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 29-14 roll on top-rated NBA picks!

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