The Boston Celtics host the San Antonio Spurs in a cross-conference NBA tilt at 7:30 p.m. ET on Wednesday. Boston is favored by 7.5 points at home, while the Over-Under is set at 223 (see up-to-date odds for every game this week on our NBA odds page). Before making any Spurs vs. Celtics picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 12 of the 2021-22 NBA season on a stunning 50-27 roll on all top-rated NBA picks, returning almost $2,000. Anyone following it has seen HUGE returns.

The model knows the Spurs are above-average on offense. San Antonio is producing 1.1 points per possession for the season, ranking in the top ten in field goal percentage at well over 46 percent. The Spurs lead the NBA in assists, averaging more than 28 per game, and San Antonio is in the top five in assist rate and turnover avoidance. San Antonio is securing more than 27 percent of offensive rebound opportunities, and the Spurs land in the top ten in second-chance points and fast break points.

The model also knows the Celtics are tremendous on defense, holding opponents to 107.3 points per 100 possessions. Boston is in the top five of the NBA in assists allowed (21.6 per game), field goal percentage allowed (44.1 percent) and two-point percentage allowed (50.6 percent). The Celtics are forcing 14.2 turnovers per game this season, and Boston is also blocking 5.7 shots per game. Boston's opponents are scoring only 43.3 points in the paint per game, and the Celtics are giving up 12.5 second-chance points per game.

Now, it has set its sights on Spurs vs. Celtics. We can tell you the model is leaning under the total, and it also says one side of the spread hits in over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Spurs vs. Celtics? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Spurs vs. Celtics spread you should be all over Wednesday, all from the model on a roll on NBA picks!