A Sun Belt showdown has the Georgia Southern Eagles (2-3) and the Southern Miss Golden Eagles (3-2) squaring off at 8 p.m. ET. Last week, Georgia Southern fell to James Madison 35-10. As for Southern Miss, they defeated Jacksonville State 42-25. 

Kickoff from Allen E. Paulson Stadium in Statesboro, Georgia, is at 8 p.m. ET. The Golden Eagles are 3.5-point favorites in the latest Southern Miss vs. Georgia Southern odds, while the over/under for total points scored is 59.5 via SportsLine consensus. The Over is a combined 7-3 for the teams this season.

Before making any Southern Miss vs. Georgia Southern picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Southern Miss vs. Georgia Southern 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 70% of simulations!

So who wins Southern Miss vs. Georgia Southern, and which side of the spread hits over 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!