Southeastern Louisiana vs. Louisville odds, line: Proven model reveals college basketball picks for Dec. 14, 2021, nonconference game

Teams looking to put weekend losses behind them meet when the Southeastern Louisiana Lions battle the Louisville Cardinals in a nonconference matchup on Tuesday. Tip-off from KFC Yum! Center in Louisville, Ky., is set for 6 p.m. ET. Louisville is favored by 23.5 points at Caesars Sportsbook, while the over-under for total points is set at 140.5 (see up-to-date odds for every game this week on our college basketball odds page).

Before making any Southeastern Louisiana vs. Louisville picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows the Cardinals have eight players averaging at least 5.8 points per game, led by senior transfer guard Noah Locke. Locke is averaging 10.7 points and 2.4 rebounds per game, reaching double figures in six games. He scored 20 points and grabbed three rebounds in just his second game with Louisville, an 80-72 overtime loss to Furman on Nov. 12. Locke played three seasons at Florida and ranks among the Gators' career top 10 in 3-pointers. He averaged 10.6 points and 2.4 rebounds per game as a junior at Florida, while making a team-high 57 of 141 3-pointers (40.4 percent).

The model also knows the Lions have eight players averaging 5.5 points or more. Leading the way is junior guard Gus Okafor at 13.5 points. He is also averaging 5.6 rebounds, 1.8 assists and 1.2 steals. Okafor has reached double figures in seven games this season, recording two double-doubles. He scored a season-high 23 points in a 90-71 loss against Florida Gulf Coast on Nov. 27.

Now, it has set its sights on Southeastern Louisiana vs. Louisville. It is leaning Over on the total and it also says one side of the spread hits in over 70 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Southeastern Louisiana vs. Louisville? And which side of the spread hits in over 70 percent of simulations? ... Join SportsLine right now to find out which side of the Southeastern Louisiana vs. Louisville spread you should be all over Tuesday, all from the model on a roll on college basketball picks!