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South Florida vs. Wyoming odds, line, spread: Proven model reveals college basketball picks, predictions for Dec. 25, 2021

The SportsLine projection model has a pick for the clash between Wyoming and South Florida. Here are the results:
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The South Florida Bulls will take on the Wyoming Cowboys at 1:30 p.m. ET Saturday at SimpliFI Arena in Honolulu as part of the Diamond Head Clasic. Wyoming is 10-2 on the season while the Bulls are 5-6. The Cowboys are favored by 7.5 points in the latest South Florida vs. Wyoming odds from Caesars Sportsbook, and the over-under is set at 122.5. Before you make any Wyoming vs. South Florida picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated South Florida vs. Wyoming 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins South Florida vs. Wyoming? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!

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SportsLine Staff