South Carolina vs. No. 7 Ole Miss odds, line: 2025 college football picks for Week 10 predictions from proven model

The seventh-ranked Ole Miss Rebels look to stay in the SEC championship race when they battle the South Carolina Gamecocks in a key matchup on Saturday. The Gamecocks are coming off a 29-22 loss to Alabama, while Ole Miss downed Oklahoma 34-26 on Oct. 25. The Gamecocks (3-5, 1-5 SEC), who are 13th in the conference, have lost three in a row. The Rebels (7-1, 4-1 SEC), who are tied for third in the league, are 5-0 on their home field in 2025.

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Kickoff from Vaught-Hemingway Stadium in Oxford, Miss., is at 7 p.m. ET. Ole Miss leads the all-time series 10-8, including a 27-3 win last year. The Rebels are 12.5-point favorites in the latest South Carolina vs. Ole Miss odds, while the over/under for total points scored is 55.5 via SportsLine consensus. 

Before making any South Carolina vs. Ole Miss picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and it enters Week 10 on a profitable 47-33 combined run on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated South Carolina vs. Ole Miss 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations.

So who wins South Carolina vs. Ole Miss, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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