South Carolina vs. Charlotte odds, line, spread: Proven model reveals college football picks, predictions for Week 4, 2022

The South Carolina Gamecocks will take on the Charlotte 49ers at 7:30 p.m. ET on Saturday at Williams-Brice Stadium. The Gamecocks are 1-2 overall and 1-1 at home, while Charlotte is 1-3 overall and 1-1 on the road. USC is ranked sixth in the SEC's East Division; the 49ers are ranked 10th in Conference USA. 

The Gamecocks are favored by 22 points in the latest South Carolina vs. Charlotte odds from Caesars Sportsbook, and the over/under is set at 69. Before you make any South Carolina vs. Charlotte picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns!

Now, it has simulated South Carolina vs. Charlotte 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins South Carolina vs. Charlotte? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!