Two teams at opposite ends of the American Athletic Conference standings collide when the SMU Mustangs and Temple Owls square off on Friday at Lincoln Financial Field in Philadelphia. The Mustangs (4-2 overall, 2-0 in AAC) enter the week in a four-way tie for first place in the conference, along with Tulane, Florida Atlantic and UTSA. Meanwhile the Owls (2-5, 0-3) sit at the bottom of the standings and are one of three teams still winless in conference play. Temple QB E.J. Warner (concussion) is questionable.

Kickoff is scheduled for 7 p.m. ET. The Mustangs are 23.5-point favorites in the latest SMU vs. Temple odds, while the over/under for total points scored is 54.5. (See up-to-date odds for every game this week on our college football odds page.)

Before you make any Temple vs. SMU picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of more than $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model knows that the Mustangs have been playing excellent defense this season. The defense ranks in the top 20 in NCAA in defensive touchdowns (seventh, two), scoring defense (18th, 17.0 points per game), total defense (19th, 311.3 yards per game) and passing yards allowed (19th, 183.5 per game). In Week 2, SMU held Oklahoma's explosive offense to season lows in total yards (365), passing yards (176) and yards per play (4.9).

The model also knows that the Owls are coming off one of their best rushing games of the season. On Saturday at North Texas, Temple ran for 242 yards. That total is the second most in a game by the Owls this season, behind the team's 290-yard performance in Week 3 against Norfolk State.

Now, the model has set its sights on SMU vs. Temple. We can tell you it is leaning Over the total, and it also says one side of the spread hits in more than 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Temple vs. SMU. and which side of the spread hits more than 50% of the time? ... Join SportsLine right now to find out which side of the SMU vs. Temple spread you should be all over Friday, all from the model that's up more than $2k on top-rated college football pick since its inception!