A pair of 2-1 teams look to get an early leg up in the ultra-competitive NFC West when the Seattle Seahawks take on the Arizona Cardinals on Thursday Night Football. Seattle is coming off a 44-13 crushing of the New Orleans Saints this past Sunday, while Arizona dropped a 16-15 decision at San Francisco in a game that came down to the wire. The Seahawks, who finished 10-7 and tied for first with the Los Angeles Rams in 2024, are 1-0 on the road this season. The Cardinals, who finished third at 8-9, are 1-0 on their home field this year and have won six of their last seven at home. However, Kyler Murray is 1-6 ATS over his last seven games versus Seattle.

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Kickoff from State Farm Field in Glendale, Ariz., is set for 8:15 p.m. ET. Seattle leads the all-time series 29-22-1, including wins in each of the last seven meetings. The Seahawks are 1.5-point favorites in the latest Seahawks vs. Cardinals odds from SportsLine consensus, after Arizona opened as 1.5-point favorites. The over-under for total points scored is 43.5. Seattle is at -129 on the money line (risk $129 to win $100), while Arizona is at +110 (risk $100 to win $110).

Before making any Seahawks vs. Cardinals picks, you NEED to see what SportsLine expert Josh Nagel has to say.

Nagel is a Reno-based analyst and radio host who has worked in the sports handicapping industry for more than 20 years. SportsLine's assistant managing editor has covered the wagering industry on a variety of platforms, and has won numerous sports handicapping contests. He prides himself on consistency and insightful analysis, and he is 25-10 (+1455) on his last 35 picks in Seattle Seahawks games. Anyone who has followed him could be WAY UP!

Nagel has analyzed Seahawks vs. Cardinals and is going Over on the total. He's also found a critical X-factor that has him jumping all over one side of the spread! 

Who wins Seahawks vs. Cardinals, and what critical X-factor has Nagel jumping on one side of the spread? ... Join SportsLine right now to find out, all from an expert who returned $1,455 to $100 players over his last 35 Seattle Seahawks picks!