Seahawks vs. 49ers prediction, line, odds: Expert reveals divisional round NFL picks for Saturday's matchup

An NFC West rivalry will be renewed in the divisional round of the 2026 NFL playoffs as the San Francisco 49ers visit the Seattle Seahawks on Saturday. The teams split their two regular-season contests, with the road team winning each game. Seattle (14-3) is coming off a bye as the No. 1 seed, and the Seahawks have reached the Super Bowl each of the three previous times they were the top overall seed. The 49ers (12-5) are coming off a road upset of the Eagles, 23-19, in the Wild Card Round and have won four straight road games at Seattle.

Kickoff is at 8 p.m. ET from Lumen Field in Seattle. The latest Seahawks vs. 49ers odds have Seattle as 7.5-point favorites at DraftKings Sportsbook, while the over/under for total points scored is 45.

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Before making any 49ers vs. Seahawks picks, you NEED to see which side SportsLine NFL expert Micah Roberts is on, considering his mastery of 49ers picks.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. Roberts has a strong read on the pulse of the 49ers. He is 19-4 (+1460) on his last 23 against-the-spread picks in games involving San Francisco!

Now, Roberts has locked in another confident against-the-spread pick for Seahawks vs. 49ers.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins 49ers vs. Seahawks in the NFL divisional round and what x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Seahawks vs. 49ers spread to back, all from the expert who is a blistering 19-4 in his last 23 San Francisco picks!