Seahawks vs. 49ers line, odds: Proven model releases spread pick for 2026 NFL Week 18 matchup on Saturday

The top seed in the NFC will be up for grabs when the Seattle Seahawks battle the San Francisco 49ers in a key NFC West matchup on Saturday night. Seattle is coming off a 28-10 win at Carolina on Sunday, while San Francisco outlasted Chicago 42-38. The Seahawks (13-3), who lead the NFC West, have won six in a row. The 49ers (12-4), who are second in the division, have also won six straight and are 9-2 within the conference. San Francisco will be without several players, including Fred Warner (ankle) and Nick Bosa (knee). George Kittle (ankle) is pushing to return for the game.

Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8 p.m. ET. The Seahawks lead the all-time series 31-24, but San Francisco has won seven of the past eight meetings. The Seahawks are 1.5-point favorites in the latest Seahawks vs. 49ers odds, while the over/under for total points scored is 41.5 via SportsLine consensus. 

Before making any Seahawks vs. 49ers picks, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Seahawks vs. 49ers.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits well over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Seahawks vs. 49ers in NFL Week 18, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the line to back, all from the model that has gone 53-37 on top-rated picks since 2024!

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