Saint Louis vs. Michigan odds, prediction: 2026 NCAA Tournament picks from proven model

The ninth-seeded Saint Louis Billikens clash with the top-seeded Michigan Wolverines in the second round of the NCAA Tournament Midwest Region on Saturday. Saint Louis advanced with a convincing 102-77 win over eighth-seeded Georgia on Thursday, while Michigan cruised to a 101-80 win over 16tth-seeded Howard. 

Tipoff from KeyBank Center in Buffalo, N.Y., is set for 12:10 p.m. ET on CBS. Michigan is a 12.5-point favorite in the latest Saint Louis vs. Michigan odds, while the over/under for total points scored is 161.5.

Before making any Saint Louis vs. Michigan picks, you NEED to see the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Saint Louis vs. Michigan 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread is the better value!

So who wins Saint Louis vs. Michigan, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!