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Rockets vs. Thunder odds, line, spread, time: 2025 NBA Opening Night picks, October 21 predictions from proven model

SportsLine's model has locked in its Tuesday NBA predictions for the Houston Rockets vs. Oklahoma City Thunder on NBA Opening Night

ByPublished: Oct 21, 2025 8:26PM UTC . 2 min read

The 2025-26 NBA season is finally here, and it will begin where last season ended. The Oklahoma City Thunder hoisted the Larry O'Brien Trophy on their home court last year, and OKC will host the Houston Rockets on NBA Opening Night on Tuesday. OKC went a franchise and league-best 68-14 last season en route to the title, while Houston went 52-30 before being knocked out in the first round of the NBA Playoffs.

Tipoff is set for 7:30 p.m. ET from the Paycom Center Oklahoma City, Okla. OKC is favored by 6.5 points in the latest Thunder vs. Rockets odds, according to the SportsLine consensus. The over/under is 227.5 points.

Before entering any Rockets vs. Thunder picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past seven seasons. The model enters the 2025-26 NBA season on a sizzling 160-118 roll on all top-rated NBA picks, returning nearly $4,000. It also went 24-11 (69%) on top-rated NBA against-the-spread picks last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Rockets vs. Thunder 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits 70% of the time in an A-rated pick!

So who wins Thunder vs. Rockets, and which side of the spread hits 70% of the time in an A-rated pick? Join SportsLine right now to see which side of the Rockets vs. Thunder spread you need to jump on, all from the computer model that has crushed its NBA picks!

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Ross Kelly

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