Rockets vs. Spurs odds, line: Proven model reveals picks for NBA matchup on Tuesday, January 20

The top two teams in the Southwest Division clash when the San Antonio Spurs battle the Houston Rockets in a key Western Conference matchup on Tuesday. San Antonio is coming off a 123-110 win over the Utah Jazz on Monday, while Houston defeated the New Orleans Pelicans 119-110 on Sunday. The Spurs (30-13), who are 7-1 within the division, are 13-8 on the road this season. The Rockets (25-15), who are 3-4 against the Southwest Division, are 14-3 on their home court. Houston will be without center Steven Adams (ankle).

Tip-off from Toyota Center in Houston is set for 8 p.m. ET. The Spurs lead the all-time series 120-100, but the Rockets have won three six of the last eight meetings. Houston is a 4.5-point favorite in the latest Spurs vs. Rockets odds from DraftKings Sportsbook, while the over/under for total points scored is 220.5. 

Before making any Spurs vs. Rockets picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 14 of the 2025-26 NBA season on a sizzling 35-15 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Spurs vs. Rockets 10,000 times and the results are in. We can tell you that the model is going Over on the point total, and it also says one side of the spread hits in nearly 70% of simulations!

Who wins Spurs vs. Rockets, and which side of the spread hits nearly 70% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 35-15 roll on top-rated NBA picks!