Rice vs. Houston odds, line, spread: Proven model reveals college football picks, predictions for Week 2, 2021

The Rice Owls will take on the Houston Cougars at 6:30 p.m. ET on Saturday at Rice Stadium. Both teams are 0-1; the Owls are 0-0 at home, while Houston is 0-0 on the road. Rice ended last year fifth in the West Division of Conference USA, while Houston ended up fourth in the AAC's West Division. 

The Cougars are favored by eight points in the latest Rice vs. Houston odds from Caesars Sportsbook, and the over-under is set at 53. Before you make any Houston vs. Rice picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Rice vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that hits in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Houston vs. Rice? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!