Reds vs. Nationals prediction, odds, line, start time: MLB picks, best bets for Wednesday, July 23, matchup from proven model

The Washington Nationals (40-60) are set to host the Cincinnati Reds (52-49) for a day game on Wednesday, July 23. The Nationals are 20-30 at home, while the Reds are 24-27 on the road this season. The Reds won three of four games over the Nationals in their prior series this season. The Nationals won the first two games of this series, including a 6-1 win on Tuesday. Nick Lodolo (7-6, 3.33 ERA) is scheduled to start for Cincinnati, while Michael Soroka (3-7, 5.10 ERA) will be on the mound for Washington.

First pitch from Progressive Field in Cleveland is set for 12:05 p.m. ET. Cincinnati is a -140 favorite on the money line (risk $140 to win $100) in the latest Nationals vs. Reds odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9 in the latest MLB odds.  

Before you make any Reds vs. Nationals picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 17 of the 2025 MLB season 46-43 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 40 units of profit. Anybody following could have seen strong returns!

The model has simulated Reds vs. Nationals 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line hits in over 60% of computer simulations!

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