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Reds vs. Cubs odds, line, start time, picks, best bets for May 30 National League Central matchup from proven model

SportsLine's projection model, which is on a 27-21 roll on top-rated MLB picks, has locked in its MLB picks for the Reds vs. Cubs on Friday at Wrigley Field

ByPublished: May 30, 2025 4:51PM UTC . 2 min read

The Chicago Cubs look to stay hot when they battle the Cincinnati Reds in a key National League Central Division matchup on Friday afternoon. The Cubs are coming off a 2-1 win over the Colorado Rockies, while the Reds dropped a 3-2 decision to the Kansas City Royals on Wednesday. The Reds (28-29), who are fourth in the division, are 5-5 in their last 10 games. The Cubs (35-21), who are first in the NL Central, are 8-2 over their past 10 games, winning four in a row.

First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET. The Cubs have won five of the past seven meetings with the Reds. Chicago is a -163 favorite on the money line (risk $163 to win $100) in the latest Reds vs. Cubs odds, while the total number of runs Vegas thinks will be scored, or the over/under, is 9 in the latest MLB odds. 

Before you make any Reds vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 10 of the 2025 MLB season on a profitable 27-21 run (56%) on top-rated MLB picks. Anybody following could have seen strong returns!

The model has simulated Reds vs. Cubs 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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Daniel Kohn

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