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Red Sox vs. Phillies odds, line, start time, picks, best bets for Monday, July 21, matchup from proven model

SportsLine's projection model, which is on a 46-43 run on top-rated MLB picks, has locked in its MLB picks for the Boston Red Sox vs. Philadelphia Phillies at Citizens Bank Park in Philadelphia

ByPublished: Jul 21, 2025 8:32PM UTC . 2 min read

The Boston Red Sox will look to stay hot as they face the Philadelphia Phillies in a key interleague matchup on Monday night. Boston is coming off a 6-1 win over the Chicago Cubs, while Philadelphia dropped an 8-2 decision to the Los Angeles Angels on Sunday. The Red Sox (54-47), third in the American League East, have won eight of their last 10 games. The Phillies (56-43), first in the National League East, have dropped six of 10.

First pitch from Citizens Bank Park in Philadelphia is set for 6:45 p.m. ET. The Red Sox have won four of the last six meetings with the Phillies, including two in a row. Philadelphia is a -228 favorite on the money line (risk $228 to win $100) in the latest Red Sox vs. Phillies odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8 in the latest MLB odds. Boston's Walker Buehler is -152 to register 3.5 or more strikeouts, while Philadelphia's Zach Wheeler is -146 to strike out 8.5 batters or fewer. 

Before you make any Red Sox vs. Phillies picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 17 of the 2025 MLB season 46-43 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 40 units of profit. Anybody following could have seen strong returns!

The model has simulated Red Sox vs. Phillies 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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Daniel Kohn

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